Cirrhosis of the Liver Causes, Symptoms & Treatment

What is Cirrhosis?

Cirrhosis is a progressive condition where scar tissue gradually replaces healthy liver cells. In time, this can affect liver function. Cirrhosis is a progressive disease that develops over many years. As scar tissue builds up, it can affect blood flow through the liver, leading to liver dysfunction.

Various factors can lead to liver damage and cirrhosis, such as:

viral infections
alcohol consumption
toxins, including medications
hereditary and genetic conditions
some autoimmune diseases
metabolic syndrome, including obesity, which leads to widespread inflammation

Fibrosis of the liver

Fibrosis of the liver occurs when the organ attempts to repair itself and scar tissue forms during the healing process. Scarring is a natural human reaction to injury, but when the liver is continually damaged–either through prolonged, heavy alcohol consumption, viral hepatitis, non-alcoholic fatty liver disease, or another cause–dead, non-functioning scar tissue accumulates.

The more scar tissue that accumulates, the more it constricts blood flow to the liver. Known as portal hypertension, this reaction deprives liver cells and leads to cell death. As a result, the organ gets caught in a cycle of damage and scarring until the liver is comprised of hardened scar tissue and loses its facility to function.

The entire body is affected by the liver’s inability to function properly, including the capacity to produce blood-clotting proteins, draw in–and eliminate–toxins, and aid with the absorption of fat and fat-soluble vitamins such as Vitamins A, D, E, and K.

Together, this has the potential to lead to life threatening complications, and death. This article looks at why cirrhosis happens and how to recognize it, as well as the treatments, complications, and outlook.

Symptoms of Cirrhosis

With early cirrhosis, there are often no cirrhosis symptoms. But, as scar tissue accumulates, it undermines the liver’s ability to function properly.

A person may notice:

fatigue
nausea
loss of appetite
weight loss and loss of muscle mass
patches of small, red blood vessels on the upper trunk and the palms of the hands

As the disease progresses, they may experience:

swelling in the legs and abdomen due to a buildup of fluid
an enlarged spleen
infections
confusion
jaundice, where the whites of the eyes take on a yellow tinge
dark-colored urine
tarry stools
itching
internal bleeding
low sex drive

In time, fibrous scar tissue replaces healthy liver tissue. Regenerative nodules may also form. These are lumps that appear as the liver tries to heal the damage.

Cirrhosis Treatment

With an early diagnosis, treating the underlying cause or complications can limit damage to the liver and complications.

Lifestyle changes

If a person has a diagnosis of cirrhosis, they will need to protect their liver, for example, by:

avoiding raw or undercooked meat and shellfish, which increase the risk of an infection
avoiding alcohol consumption
limiting the intake of salt, fat, and protein, if a doctor recommends it
using diet and exercise to manage body weight, if appropriate

Treating underlying causes

Some treatment options will depend on the underlying cause.

For example:

Alcohol-related liver disease: A doctor will recommend taking no alcohol. In some cases, they may recommend a special treatment program for people with alcohol dependency.
Hepatitis B or C: A doctor will prescribe antiviral medications.
Non-alcoholic-related fatty liver disease (NAFLD): Lifestyle changes, such as a change in diet, may help manage NAFLD.

Treatment for symptoms

The person may also need treatment for symptoms of cirrhosis, such as:

Portal hypertension: Medication can reduce high blood pressure in the portal vein, which supplies the liver with blood.
Esophageal varices: Swollen blood vessels can burst, causing bleeding to appear in vomit or stools. This needs urgent medical attention. Various strategies can help stem the bleeding.
Infections: Antibiotics can treat bacterial infections.
Hepatic encephalopathy: Medications can help manage high toxin levels in the blood.

Screening

A doctor may also recommend screening for liver cancer, as the risk is higher among people with cirrhosis. People living with cirrhosis may need regular blood tests and imaging scans.

Liver transplant

Widespread scarring may be irreversible. In these cases, the person may need a liver transplant. It can take time to find a suitable donor, and this procedure is often a last resort.

Stages

Doctors grade cirrhosis in various ways, such as the Childs-Pugh score. Using scores from various tests, it puts the liver into one of three categories:

A: The liver is working well.
B: There is moderate damage.
C: Damage is advanced or severe.

The score helps give an idea of the person’s outlook. Category C, or end-stage liver disease, is potentially fatal. Cirrhosis can also be either compensated or decompensated.

With compensated cirrhosis, the liver can function effectively despite the damage. People with compensated cirrhosis often have no symptoms. With decompensated cirrhosis, the liver cannot function effectively, and symptoms may be noticeable.

Causes of Cirrhosis

Common cirrhosis of the liver causes are:

hepatitis, a viral infection
long-term high alcohol consumption
non-alcohol-related steatosis, a type of fatty liver disease
exposure to toxins
genetic diseases

Hepatitis

Globally, hepatitis B and C are the leading causes of cirrhosis. People can get either type after exposure to blood that contains the virus, for example, through needlestick injuries or sharing needles. Vaccines can protect against hepatitis B but not hepatitis C.

In autoimmune hepatitis, the person has an autoimmune disease. In this type of disease, the immune system mistakenly attacks healthy cells. Sometimes, an autoimmune disease can affect the liver, leading to hepatitis and cirrhosis.

Alcohol-related fatty liver disease

The liver breaks down toxins, including alcohol. But, if toxin levels are too high, the liver will be unable to process them effectively, and damage to liver cells will result. There are three stages of alcohol-related liver disease:

Alcohol-related fatty liver or steatosis: Small fat droplets accumulate in the liver.
Alcohol-related hepatitis: There is inflammation in the liver cells, causing swelling. At this stage, stopping alcohol consumption may repair the liver.
Cirrhosis: Irreversible damage can lead to potentially life threatening complications.

People who consume 30–50 grams (g) of alcohol per day for 5 years have a risk of alcohol-related liver disease. Males who consume more than 21 units per week and females who consume more than 14 units per week are at risk of steatosis due to alcohol consumption.

In the U.S., alcohol consumption is the leading cause of liver disease.

Non-alcohol-related fatty liver disease

Doctors diagnose non-alcohol-related fatty liver disease (NAFLD) when fat accumulates in over 5% of liver cells, and there is no other explanation.

NAFLD included non-alcohol-related fatty liver (NAFL) and non-alcohol-related steatosis (NASH). In NAFL, there are fatty deposits. In NASH, inflammation and cell damage are also present.

NAFLD is more likely to affect people with:

metabolic syndrome, including obesity, diabetes, high cholesterol, and high blood pressure
polycystic ovary syndrome (PCOS)
genetic conditions, such as Wilson’s disease, when copper accumulates in the liver and other parts of the body
conditions involving a nutritional imbalance, such as kwashiorkor

Other conditions

Other diseases and conditions that can contribute to cirrhosis include:

cystic fibrosis
primary sclerosing cholangitis, or hardening and scarring of the bile ducts
galactosemia, or inability to process sugars in milk
schistosomiasis, a parasitic disease
biliary atresia, which affects the formation of bile ducts before birth
glycogen storage disease, when the body has problems storing and releasing the energy release that is vital for cell function
hemochromatosis, when iron accumulates in the liver and other parts of the body
Budd-Chiari syndrome, when blood clots in the hepatic vein lead to liver enlargement and the development of new blood vessels
cancer of the bile ducts or pancreas, which can lead to blockages in the bile ducts

Diagnosis

Symptoms rarely appear in the early stages, so diagnosis often occurs when testing for another condition or disease.

If a doctor suspects cirrhosis, they will:

carry out a physical examination, including checking for swelling in the upper abdomen
ask the person about their personal and family medical history
ask about their lifestyle, including dietary habits and alcohol consumption

They may also recommend the following tests:

blood tests to check liver function
imaging tests such as an ultrasound, CT, or MRI scan to look for signs of enlargement, scarring, or nodules
a biopsy, which takes a tissue sample for testing in a laboratory

Complications

Cirrhosis can affect a range of body organs, including the:

gastrointestinal system
blood and cardiovascular system
kidneys
lungs
skin and nails
hormones

It can lead to several other conditions, some of which are life threatening.

Ascites or edema

Ascites is a buildup of fluid in the abdomen, and edema is a buildup of fluid in the legs. A low-salt diet and diuretics, or water pills, can help manage fluid levels. In severe cases, a doctor may need to drain the fluid repeatedly.

Varices and portal hypertension

Large, swollen veins develop in the esophagus and stomach. They can put pressure on a blood vessel called the portal vein, which carries blood from the spleen and bowel to the liver, leading to portal hypertension. Varices can rupture, causing bleeding and clots.

Hepatic encephalopathy

This refers to high levels of toxins in the blood where the liver can no longer filter them effectively.

Hepatocellular carcinoma

This is the most common type of liver cancer and can result from cirrhosis due to hepatitis B or C infection. Research from 2013 suggests it is becoming more common in the U.S. and globally and has a high fatality rate.

Hepatopulmonary syndrome

Hepatopulmonary syndrome (HPS) refers to a combination of:

liver disease
dilated blood vessels in the lungs
problems with the exchange of gases in the lungs

HPS is a potentially life threatening condition.

Coagulation disorders

Cirrhosis can cause problems with blood clotting, leading to bleeds and clots that can sometimes be fatal.

Outlook

There is no cure for cirrhosis, and it can be life threatening. How long a person will survive with cirrhosis depends on various factors, including:

the cause
the severity of the scarring
their age and overall health
how they treat the condition

As the disease progresses, the prognosis worsens. People with compensated cirrhosis, when the liver can still function, have a 47% chance of surviving another 10 years compared with people who do not have cirrhosis. Once cirrhosis starts to affect liver function, the chance of surviving another 10 years falls to around 16%.

People who consumed alcohol before their diagnosis and then quit have a better outlook, especially if they stopped in the earlier stages. In the United States, 4.5 million people, or 1.8% of the adult population, have liver disease. Cirrhosis accounts for 15.8 deaths in every 100,000.

Prevention

Cirrhosis is not always avoidable, but some tips can help lower the risk:

Follow a varied diet that is low in processed foods and added fats.
Keep within the recommended guidelines for the consumption of alcohol.
Use diet and exercise to maintain a suitable weight and avoid obesity.
Use a condom during sex to lower the risk of hepatitis.
Never share needles and take care when dealing with blood.
Avoid alcohol if any stage of liver disease is present.
Ask about vaccinations for hepatitis B if you are at risk.

FAQ

Here are some answers to questions people often ask about cirrhosis of the liver.

What are the stages of cirrhosis?

There are different ways to describe the progression of cirrhosis. The Child-Pugh system describes three stages, based on test results.

In this system:

Stage A: The liver is working well.
Stage B: There some impact on liver function.
And Stage C: Liver function is severely affected.

Doctors also refer to compensated cirrhosis, where damage is present, but the liver is functioning; and decompensated cirrhosis, where damage affects liver function.

Can a person survive cirrhosis?

The outlook will depend on various factors, including the cause of cirrhosis and the stage at diagnosis.

A person who receives a diagnosis in the early stage can continue to live a healthy life, but they may need to take measures, such as avoiding alcohol and maintaining a suitable weight. Once cirrhosis starts to affect liver function, the impact on a person’s outlook becomes more severe.

What are the early warning signs of cirrhosis?

Often, a person will not notice any symptoms until a later stage, when cirrhosis begins to affect liver function.

As it progresses, cirrhosis can cause a wide range of symptoms, including fatigue, nausea, low appetite, jaundice, swelling, and itchy skin.

What causes cirrhosis of the liver?

Alcohol Use Disorder (AUD) is one of the leading causes of liver disease. Other causes of cirrhosis include:

Primary Sclerosis Cholangitis
Nonalcoholic Fatty Liver Disease (NAFLD)
Chronic Hepatitis B
Chronic Hepatitis C
Hepatitis D
Non-alcoholic Steatohepatitis (NASH)
Hemochromatosis
Autoimmune Disorders, such as Primary Biliary Cirrhosis
Wilson’s Disease

Cirrhosis is also caused by over-the-counter (OTC) and prescription drugs, including antibiotics, anti-depressants, and pain relievers such as acetaminophen.

Further, a poor diet and obesity are contributing factors to the development of nonalcoholic fatty liver disease. The use of illegal drugs, such as cocaine, also increases the chances of liver disease

What are the first signs of cirrhosis of the liver?

Any of the following symptoms necessitate immediate medical attention.

Jaundice or yellowing of the eyes or skin.
Pain and distention of the abdomen due to the release of fluid from the liver.
Swelling of the lower legs due to fluid retention.
Confusion or forgetfulness. …
Dark-colored urine.
Pale-colored stool.

Is cirrhosis reversible?

Although the damage caused by cirrhosis is not reversible, treatment can slow the progression of the disease, alleviate symptoms, and prevent complications. In cases of early cirrhosis, it is possible to minimize damage to the liver by tackling the underlying causes.

How long can you live with cirrhosis of the liver?

Patients with compensated cirrhosis have a median survival that may extend beyond 12 years. Patients with decompensated cirrhosis have a worse prognosis than do those with compensated cirrhosis; the average survival without transplantation is approximately two years.

How long can you live with cirrhosis if you stop drinking?

It’s generally not reversible, but stopping drinking alcohol immediately can prevent further damage and significantly increase your life expectancy. A person who has alcohol-related cirrhosis and doesn’t stop drinking has a less than 50% chance of living for at least 5 more years.

What causes cirrhosis of liver in women?

The most common causes of cirrhosis among women are hepatitis C, autoimmune etiologies, nonalcoholic steatohepatitis, and alcoholic liver disease. For most chronic liver diseases, the risk of progression to cirrhosis and rates of liver failure and hepatocellular carcinoma are lower in women than in men.

Woman Liver Cirrhosis Symptoms

Symptoms of cirrhosis

tiredness and weakness.
loss of appetite.
weight loss and muscle wasting.
feeling sick (nausea) and vomiting.
tenderness or pain around the liver area.
tiny red lines (blood capillaries) on the skin above waist level.
very itchy skin.
yellowing of the skin and the whites of the eyes (jaundice)

Bottom line

Cirrhosis results when tissue damage causes scarring in the liver. Possible causes include a hepatitis infection, high consumption of alcohol, some genetic conditions, and inflammation that occurs with obesity and metabolic disorder.

In the early stages, damage is present and scarring start to appear, but the liver continues to function. In time, scarring becomes widespread. Eventually, the liver is unable to function.

Some ways of reducing the risk include limiting alcohol consumption, maintaining a moderate body weight, and taking measures to prevent infection with hepatitis B and C.

For people with early-stage cirrhosis, lifestyle changes — such as avoiding alcohol consumption, protecting against infection, and managing body weight — can improve their outlook.

When cirrhosis starts to affect liver function, it can become life threatening. For this reason, it is best to take measures to prevent cirrhosis where possible.

This article above expounds everything you need to know about cirrhosis of the liver; causes, symptoms and treatment.

Also Read: 13 Foods that Cleanse or Detox your Liver Naturally

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